Teenage social outcast Peter Parker spends his days trying to unravel the mystery of his own past and winning the heart of his high school crush, Gwen Stacy. Peter discovers a mysterious briefcase belonging to his father, who abandoned him when he was a child, which leads him to his dad's former partner, Dr. Curtis Connors. The discovery of his father's secret will ultimately shape his destiny of becoming "Spider-Man" and brings him face to face with Connors, who becomes the vicious and vengeful Lizard.